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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidney of diabeticmice.Imaging results showed that the pH value in kidney of diabetic mice was lower than that of the normalmice, while the pH value in liver of diabetic mice was almost the same as that of the normal mice.

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 386-392 doi: 10.1007/s11684-017-0574-z

Abstract: Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood.Diabetic retinopathy (78.4%) was a crucial complication in patients with DN.

Keywords： diabetic nephropathy     clinical characteristics     renal biopsy     outcomes    

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Hyperglycemic memory in diabetic cardiomyopathy

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 25-38 doi: 10.1007/s11684-021-0881-2

Abstract: Cardiovascular diseases account for approximately 80% of deaths among individuals with diabetes mellitus, with diabeticcardiomyopathy as the major diabetic cardiovascular complication.herein the current advances that have been achieved in research on the underlying mechanisms of HGM in diabetic

Keywords： diabetes     diabetic cardiomyopathy     hyperglycemic memory    

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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).patients with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetickidney disease (NADKD) or nonalbuminuric diabetic nephropathy.Epidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAymice model.and upregulate the expression of IRS-1, PI3K (p85), p-Akt, and GLUT4 in the skeletal muscle of KKAy mice

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract:

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 301-305 doi: 10.1007/s11684-013-0283-1

Abstract: However, the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism isAdiponectin (APN) is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory propertiesHowever, the effect of APN on myocardial injury in diabetic subjects, especially its potential in restoringthe sensitivity of the diabetic heart to IPostC has not been investigated.In the current paper, we discussed the possible reasons why the myocardium of diabetic subjects loses

Keywords： adiponectin     ischemic post-conditioning     ischemia reperfusion injury     diabetes    

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Inhibitory activity of Bifidobacterium adolescent combined with cisplatin on melanoma in mice and its

HUANG Hongying, LIU Guangchao, QI Yijun, DU Yaowu, CHEN Jugao, MA Yuanfang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 186-190 doi: 10.1007/s11684-008-0035-9

Abstract: inhibitory activity of Bifidobacterium adolescent combined with cisplatin on the growth of melanoma (B16) in miceC57 mice were inoculated with B16 cancer cells to construct mouse model of melanoma and treated withThe ratio of inhibitory activity reached 74.45% when the mice were treated by bifidobacterium combinedthe inhibitory activity on B16 cell proliferation is correlated with the enhanced immune activity in mice
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Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 750-766 doi: 10.1007/s11684-021-0839-4

Abstract: acetylation, airway inflammation, and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice

Keywords： particulate matter 2.5     sirtuin 2     p65     airway inflammation     bronchial hyperresponsiveness     triptolide    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract: polysaccharide conjugate vaccine with the pneumococcal surface adhesin A (PsaA) protein carrier in young miceA total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine.Furthermore, the third group of 15 young mice was inoculated with phosphate buffer saline as control.The immunized mice were inoculated with pneumococcus in the middle ear.

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 212-218 doi: 10.1007/s11684-016-0438-y

Abstract:

Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX). Gene therapy might be the ultimate strategy for the disease. However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safety. Self-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring low immunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia B gene therapy. A strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced into plasmid scAAV8-LP1 to develop an optimized AAV8 vector that expresses human clotting factor FIX (hFIX). The efficiency of scAAV8-LP1-hFIX administered through normal systemic injection or hydrodynamic injection was compared. A high expression was achieved using hydrodynamic injection, and the peak hFIX expression levels in the 5×1011 and 1×1011 virus genome (vg) cohorts were 31.94% and 25.02% of normal level, respectively, at 60 days post-injection. From the perspective of long-term (200 days) expression, both injection methods presented promising results with the concentration value maintained above 4% of normal plasma. The results were further verified by enzyme-linked immunosorbent assay and activated partial thromboplastin time. Our study provides a potential gene therapy method for hemophilia B.

Keywords： hemophilia B     AAV8     hFIX     gene therapy    

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Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabeticThe associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem fromwhether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetes, or diabeticIn fact, it is known that Zn deficiency is a common phenomenon in diabetic patients.Theoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complications

Keywords： zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Diabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract: The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice.Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Title Author Date Type Operation

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy

Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li

Journal Article

Hyperglycemic memory in diabetic cardiomyopathy

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic

Tingting Wang, Shanglong Yao, Zhengyuan Xia, Michael G. Irwin

Journal Article

Inhibitory activity of Bifidobacterium adolescent combined with cisplatin on melanoma in mice and its

HUANG Hongying, LIU Guangchao, QI Yijun, DU Yaowu, CHEN Jugao, MA Yuanfang

Journal Article

Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX

Wei Lu,Qingzhang Zhou,Hao Yang,Hao Wang,Yexing Gu,Qi Shen,Jinglun Xue,Xiaoyan Dong,Jinzhong Chen

Journal Article

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article